Pathologic features of small hepatocellular carcinoma: analysis of 61 cases
نویسندگان
چکیده
Small hepatocellular carcinoma (HCC) is defined as hepatocellular carcinoma measuring less than 2 cm in diameter. Sixty-one cases of small HCC were analyzed to investigate the pathologic features of small HCC. Sixty-one cases of small HCC were selected from HCC cases which underwent surgical resection at Yeungnam University Hospital. The pathologic findings were analyzed. There were 48 male patients and 13 female patients, with ages ranging from 37 to 75 years (median, 57 years). Hepatitis B virus infection was present in 75.4% (46/61), hepatitis C virus infection in 11.4% (7/61), and alcoholic liver disease in 6.6% (4/61). Cirrhosis was present in 77.0% (47/61). Grossly, vaguely nodular type was present in 16.4% (10/61) and distinctly nodular type in 83.6% (51/61). Histologically, well differentiated type was present in 62.3% (38/61), moderately differentiated type in 36.1% (22/61), and poorly differentiated type in 1.6% (1/61). Vascular invasion was present in 8.2% (5/61). In the non-neoplastic liver, high grade dysplastic nodule was present in 16.4% (10/61). In conclusion, a large percentage of small HCCs are well differentiated. The majority of small HCCs arise in cirrhotic liver. Hepatitis B virus infection is the most common cause of small HCCs in Korea.
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